@Johnnyjax if this is your very first complex project, I would recommend you to stick as closely as possible to the reference board ... if you are not experienced enough and if you do too many changes you may end up with a non working board. Of course you can change power supplies and of course you can change memory topology .... but you need to know what you are doing. But, based on the questions, you do not know what to do and how to do it - so I am not sure if making too many changes is the best idea.
What is your priority? Would you like to design a board were you practice and everything is working when finished, you will get confidence and you can use the board to show it to you possible employer or you would like to design something what you do not know exactly how to design, it is a great and super exciting challenge and if working then it will be fantastic achievement, but you are going into a very high risk, that the board is not going to work?
People will look if what you design is working ... they will not care much about what power supply or memory topology you used. If you have decided to design that board then paying a little bit more extra for working board is much more valuable than trying to save and end up with a board which may not work.
Do not take me wrong, but if designing complex boards would be so simple that anyone after watching a video could do that, we would have world full of great engineers. Designing boards is also about experience and skills ... and trying to design a complex board with a little experience is risky. Therefore it is safer to stay as close as possible with to what works. But ... that is just my opinion, maybe I am too careful